APOE told me put my fat in the bag and nobody gets hurt.

Kim, Garam; Gitler, Aaron D · Cell · 2022

editorial · Level V

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Abstract

The ε4 variant in the APOE gene is the strongest genetic risk factor for Alzheimer's disease. How does this gene impact different cell types in the brain to increase disease risk? In this issue of Cell, TCW and colleagues report APOE-driven cell-type-specific changes that may contribute to Alzheimer's disease risk.

Medical subject headings