BacPROTACs to basics: Targeted protein degradation in bacteria.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35750029.
- Also identified by DOI 10.1016/j.cell.2022.05.026.
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Abstract
Targeted protein degradation has emerged as a powerful tool for therapeutic development and biological exploration. In this issue of Cell, Morreale et al. report the development of the BacPROTAC technology to enable targeted protein degradation in Gram-positive bacteria and mycobacteria via reprogramming of Clp proteases.
Medical subject headings
- Bacteria
- Endopeptidase Clp