TIR domains as two-tiered enzymes to activate plant immunity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35750031.
- Also identified by DOI 10.1016/j.cell.2022.05.025.
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Abstract
Plant immune receptors often contain TIR domains, which can oligomerize to form active enzyme complexes in response to pathogen infections. In this issue of Cell, Yu and colleagues discover that some plant TIR domains possess a novel 2',3'-cAMP/cGMP synthetase activity that cleaves double-stranded RNA/DNA, triggering cell death during plant immune responses.
Medical subject headings
- Plant Immunity
- Receptors, Immunologic