New antivirals exploit viral feedback tricks for a cure without resistance.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35750032.
- Also identified by DOI 10.1016/j.cell.2022.05.023.
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Abstract
Many approved drugs, including antivirals, are small-molecule inhibitors of disease-causing proteins. Such inhibitors often elicit resistance during treatment. Chaturvedi et al. propose new, feedback-disruptor (FD) antivirals that efficiently cure infected cells from viruses and minimize the chance of resistance, providing a new paradigm to treat viral infections and possibly other diseases.
Medical subject headings
- Antiviral Agents
- Virus Diseases