Differences in New Variant of Concern Replication at Physiological Temperatures In Vitro.

Stauft, Charles B; Sangare, Kotou; Wang, Tony T · J Infect Dis · 2023

basic_science · Level V

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Abstract

Using multiple cell types and isolates of Delta and Omicron variants of SARS-CoV-2, we report differences in virus production, replication, and infectivity in vitro. Ancestral and Delta SARS-CoV-2 variant exhibit reduced virus production and replication at 34°C compared to 37°C while Omicron replication is balanced between temperatures.

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