POLYRETINA restores light responses in vivo in blind Göttingen minipigs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35760775.
- Also identified by DOI 10.1038/s41467-022-31180-z and PMC identifier 9237028.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Retinal prostheses hold the potential for artificial vision in blind people affected by incurable diseases of the outer retinal layer. Available technologies provide only a small field of view: a significant limitation for totally blind people. To overcome this problem, we recently proposed a large and high-density photovoltaic epiretinal device, known as POLYRETINA. Here, we report the in vivo assessment of POLYRETINA. First, we characterise a model of chemically-induced blindness in Göttingen minipigs. Then, we develop and test a minimally invasive injection procedure to insert the large epiretinal implant into the eye. Last, we show that POLYRETINA restores light-evoked cortical responses in blind animals at safe irradiance levels. These results indicate that POLYRETINA holds the potential for artificial vision in totally blind patients affected by retinitis pigmentosa.
Medical subject headings
- Retinitis Pigmentosa
- Visual Prosthesis
- Persons with Visual Disabilities