Polyfunctional Antigen Specific CD4+ T cell Responses in Patients With Human Immunodeficiency Virus/AIDS and Histoplasmosis Immune Reconstitution Inflammatory Syndrome.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 35767272.
- Also identified by DOI 10.1093/cid/ciac514 and PMC identifier 10169433.
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Abstract
In the combination antiretroviral era, there are limited data regarding the pathogenesis of histoplasmosis immune reconstitution inflammatory syndrome (IRIS) in people with human immunodeficiency virus (HIV). We immunologically characterized 10 cases of histoplasmosis, 4 of whom developed histoplasmosis IRIS. CD4+ T cells in histoplasmosis IRIS demonstrated a significant polyfunctional cytokine response to histoplasma antigen.
Medical subject headings
- Acquired Immunodeficiency Syndrome
- Histoplasmosis
- Immune Reconstitution Inflammatory Syndrome
- HIV Infections