Heat-fueled enzymatic cascade for selective oxyfunctionalization of hydrocarbons.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35768427.
- Also identified by DOI 10.1038/s41467-022-31363-8 and PMC identifier 9243031.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Heat is a fundamental feedstock, where more than 80% of global energy comes from fossil-based heating process. However, it is mostly wasted due to a lack of proper techniques of utilizing the low-quality waste heat (<100 °C). Here we report thermoelectrobiocatalytic chemical conversion systems for heat-fueled, enzyme-catalyzed oxyfunctionalization reactions. Thermoelectric bismuth telluride (Bi<sub>2</sub>Te<sub>3</sub>) directly converts low-temperature waste heat into chemical energy in the form of H<sub>2</sub>O<sub>2</sub> near room temperature. The streamlined reaction scheme (e.g., water, heat, enzyme, and thermoelectric material) promotes enantio- and chemo-selective hydroxylation and epoxidation of representative substrates (e.g., ethylbenzene, propylbenzene, tetralin, cyclohexane, cis-β-methylstyrene), achieving a maximum total turnover number of rAaeUPO (TTN<sub>rAaeUPO</sub>) over 32000. Direct conversion of vehicle exhaust heat into the enantiopure enzymatic product with a rate of 231.4 μM h<sup>-1</sup> during urban driving envisions the practical feasibility of thermoelectrobiocatalysis.
Medical subject headings
- Hot Temperature
- Hydrogen Peroxide