Effect of vaccination on household transmission of SARS-CoV-2 Delta variant of concern.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 35773247.
- Also identified by DOI 10.1038/s41467-022-31494-y and PMC identifier 9244879.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Effective vaccines protect individuals by not only reducing the susceptibility to infection, but also reducing the infectiousness of breakthrough infections in vaccinated cases. To disentangle the vaccine effectiveness against susceptibility to infection (VE<sub>S</sub>) and vaccine effectiveness against infectiousness (VE<sub>I</sub>), we took advantage of Danish national data comprising 24,693 households with a primary case of SARS-CoV-2 infection (Delta Variant of Concern, 2021) including 53,584 household contacts. In this setting, we estimated VE<sub>S</sub> as 61% (95%-CI: 59-63), when the primary case was unvaccinated, and VE<sub>I</sub> as 31% (95%-CI: 26-36), when the household contact was unvaccinated. Furthermore, unvaccinated secondary cases with an infection exhibited a three-fold higher viral load compared to fully vaccinated secondary cases with a breakthrough infection. Our results demonstrate that vaccinations reduce susceptibility to infection as well as infectiousness, which should be considered by policy makers when seeking to understand the public health impact of vaccination against transmission of SARS-CoV-2.
Medical subject headings
- COVID-19
- Vaccines