Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection With accumulation of mutations in a patient with poorly controlled Human Immunodeficiency Virus infection.

Maponga, Tongai G; Jeffries, Montenique; Tegally, Houriiyah; Sutherland, Andrew; Wilkinson, Eduan; Lessells, Richard J; Msomi, Nokukhanya; van Zyl, Gert et al. · Clin Infect Dis · 2023

case_report · Level V

Where this comes from

Abstract

A 22-year-old woman with uncontrolled advanced human immunodeficiency virus (HIV) infection was persistently infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta variant for 9 months, the virus accumulating >20 additional mutations. Antiretroviral therapy suppressed HIV and cleared SARS-CoV-2 within 6 to 9 weeks. Increased vigilance is warranted to benefit affected individuals and prevent the emergence of novel SARS-CoV-2 variants.

Medical subject headings