Diabesity? No worries, FKBP11 to the rescue.
Level V
Where this comes from
- Record sourced from PubMed, PMID 35793657.
- Also identified by DOI 10.1016/j.cmet.2022.06.006.
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Abstract
Obesity-induced type 2 diabetes, or diabesity, is associated with ER stress, UPR activation, and insulin resistance through poorly understood mechanisms. Herrema et al. (2022) report that the XBP1 target FKBP11 is repressed in the obese mouse liver and that its re-expression activates a protective UPR pathway that restores insulin sensitivity.
Medical subject headings
- Diabetes Mellitus, Type 2
- Insulin Resistance
- Tacrolimus Binding Proteins