Human Down syndrome microglia are up for a synaptic feast.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35803219.
- Also identified by DOI 10.1016/j.stem.2022.06.008.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this issue of Cell Stem Cell, Jin et al. report that human Down syndrome microglia exhibit enhanced synaptic engulfment and accelerated tau-induced cellular senescence in human-mouse chimeric brains. They show that inhibiting interferon signaling rescues both developmental and tau-associated phenotypes, rendering it a potential therapeutic target for Down syndrome.
Medical subject headings
- Down Syndrome
- Microglia