Breaking down a gut-to-brain circuit that prevents malabsorption.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35803241.
- Also identified by DOI 10.1016/j.cell.2022.06.012.
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Abstract
The ileal brake is an important reflex that ensures proper absorption of nutrients. This involves intestinal GLP-1 release, which recruits an enteric-sympathetic-spinal pathway to inhibit gastric motility and appetite. This visceral alarm system could be targeted to treat obesity and gastrointestinal dysfunction.
Medical subject headings
- Gastrointestinal Diseases
- Glucagon-Like Peptide 1