Transcription factor hijacking in the name of tolerance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35803243.
- Also identified by DOI 10.1016/j.cell.2022.06.026.
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Abstract
Thymus epithelial cells (TECs) express antigens from peripheral tissues to select against autoreactive T cells and thus prevent autoimmunity. Michelsen et al. now show that molecularly defined clusters of thymic epithelial cells express and depend on skin-, lung-, liver- or intestinal-cell transcription factors that are co-opted by the thymus to drive ectopic gene expression.
Medical subject headings
- Immune Tolerance
- Transcription Factors