Timing is everything: structural insights into the disease-linked Kv3 channels controlling fast action-potential firing in the brain.
Level V
Where this comes from
- Record sourced from PubMed, PMID 35840565.
- Also identified by DOI 10.1038/s41467-022-31537-4 and PMC identifier 9287389.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Kv3 channels enable neurons to fire at very high frequencies (>100 Hz) which is fundamental to brain development and our ability to make sense of the world at large. Cryo-EM and structure-function studies by Chi et al. now uncover Kv3 channel gating mechanisms and support new precision medicine approaches for CNS diseases.
Medical subject headings
- Brain
- Shaw Potassium Channels