Structural basis for the activation and ligand recognition of the human oxytocin receptor.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35851571.
- Also identified by DOI 10.1038/s41467-022-31325-0 and PMC identifier 9293896.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The small cyclic neuropeptide hormone oxytocin (OT) and its cognate receptor play a central role in the regulation of social behaviour and sexual reproduction. Here we report the single-particle cryo-electron microscopy structure of the active oxytocin receptor (OTR) in complex with its cognate ligand oxytocin. Our structure provides high-resolution insights into the OT binding mode, the OTR activation mechanism as well as the subtype specificity within the oxytocin/vasopressin receptor family.
Medical subject headings
- Oxytocin
- Receptors, Oxytocin