Imiquimod-Associated Localized Skin Ulceration in a Patient With Uncontrolled Diabetes.

Abstract

Human papillomavirus, one of the most common viral infections worldwide, frequently manifests as condyloma acuminata, or anogenital warts. First-line treatment of this condition includes the use of imiquimod, a topical immunomodulator. We describe a case of a localized skin ulceration necessitating surgical debridement after the use of topical imiquimod for 24 hours in a patient with uncontrolled type 2 diabetes mellitus. After debridement, the patient's wound healed appropriately, with regular wound clinic visits and diabetes education. Health care professionals should use caution when prescribing imiquimod in patients with uncontrolled type 2 diabetes mellitus.