Genetic and environmental variation impact transferability of polygenic risk scores.
Where this comes from
- Record sourced from PubMed, PMID 35858592.
- Also identified by DOI 10.1016/j.xcrm.2022.100687 and PMC identifier 9381406.
- Licence recorded as CC BY-NC-ND.
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Abstract
Even when polygenic risk scores (PRSs) are trained in African ancestral populations, Kamiza and colleagues showed that genetic and environmental variation within sub-Saharan African populations impacts prediction performance, highlighting the challenges of clinical implementation of PRSs for risk assessment.
Medical subject headings
- Genetic Predisposition to Disease
- Multifactorial Inheritance