Osteoimmunology in periodontitis; a paradigm for Th17/IL-17 inflammatory bone loss.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35870792.
- Also identified by DOI 10.1016/j.bone.2022.116500 and PMC identifier 10448972.
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Abstract
Periodontitis is a prevalent human disease of inflammation-induced bone destruction. Through studies in patient lesions of rare and common forms of periodontitis and animal model experimentation, Th17/IL-17 related immune pathways have emerged as mediators of disease pathology. In this focused review, we examine mechanisms of induction, amplification and pathogenicity of Th17 cells in periodontitis.
Medical subject headings
- Alveolar Bone Loss
- Periodontitis