Heparin, klotho, and FGF23: the 3-beat waltz of the discordant heart.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35870810.
- Also identified by DOI 10.1016/j.kint.2022.05.009.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Excess fibroblast growth factor (FGF) 23 signaling in patients with chronic kidney disease induces left ventricular hypertrophy. In this issue, Yanucil et al. investigated the interaction of soluble klotho and heparin with FGF23 and FGF receptor isoforms. They concluded that heparin promotes the FGF23-FGF receptor isoform 4 interaction and FGF23 pathogenic effects, supporting an important role of heparin in the pathogenesis of FGF23-mediated left ventricular hypertrophy in chronic kidney disease.
Medical subject headings
- Glucuronidase
- Renal Insufficiency, Chronic