Photo-enhanced upcycling H<sub>2</sub>O<sub>2</sub> into hydroxyl radicals by IR780-embedded Fe<sub>3</sub>O<sub>4</sub>@MIL-100 for intense nanocatalytic tumor therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35872555.
- Also identified by DOI 10.1016/j.biomaterials.2022.121687.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Reactive oxygen species (ROS)-based nanocatalytic tumor therapy is alluring owing to the capability to generate highly cytotoxic ∙OH radicals from tumoral H<sub>2</sub>O<sub>2</sub>. However, the antitumor efficacy is highly dependent on the radical generation efficiency and challenged by the high levels of antioxidative glutathione (GSH) in cancer cells. Herein, we report an IR-780 decorated, GSH-depleting Fe<sub>3</sub>O<sub>4</sub>@MIL-100 (IFM) nanocomposite for photo-enhanced tumor catalytic therapy by extensive production of ∙OH, which is realized by an integration of excellent peroxidase-like activity of IFM, selective upregulation of tumoral H<sub>2</sub>O<sub>2</sub> by β-lapachone, and localized hyperthermia by near infrared light irradiation. IFM shows potentiated antiproliferative effect in 4T1 cancer cells by ∙OH overproduction and glutathione scavenging, inducing intracellular redox dyshomeostasis and cell death by concurrent apoptosis and ferroptosis. In vivo antitumor investigation further demonstrates photoacoustic and fluorescence imaging-guided combinational therapy with a tumor inhibition rate of 96.4%. This study provides a strategy of photo-enhanced nanocatalytic tumor therapy by tumor-specific H<sub>2</sub>O<sub>2</sub> amplification and hyperthermia.