ToxSTAR: drug-induced liver injury prediction tool for the web environment.

Abstract

Drug-induced liver injury (DILI) is a challenging endpoint in predictive toxicology because of the complex reactive metabolites that cause liver damage and the wide range of mechanisms involved in the development of the disease. ToxSTAR provides structural similarity-based DILI analysis and in-house DILI prediction models that predict four DILI subtypes (cholestasis, cirrhosis, hepatitis and steatosis) based on drug and drug metabolite molecules. ToxSTAR is freely available at https://toxstar.kitox.re.kr/. Supplementary data are available at Bioinformatics online.