Viral Load Dynamics in SARS-CoV-2 Omicron Breakthrough Infections.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 35906927.
- Also identified by DOI 10.1093/infdis/jiac290 and PMC identifier 9384619.
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Abstract
To determine viral dynamics in Omicron breakthrough infections, we measured severe acute respiratory syndrome coronavirus 2 RNA in 206 double-vaccinated or boostered individuals. During the first 3 days following the onset of symptoms, viral loads were significantly higher (cycle threshold [Ct], 21.76) in vaccinated compared to boostered (Ct, 23.14) individuals (P = .029). However, by performing a longitudinal analysis on 32 individuals over 14 days, no difference in the viral load trajectory was observed between double-vaccinated and boostered patients. Our results indicate that booster immunization results in a reduction in detectable viral loads without significantly changing viral load dynamics over time.
Medical subject headings
- COVID-19