Diagnostic yield of simultaneous dynamic contrast-enhanced magnetic resonance perfusion measurements and [¹⁸F]FET PET in patients with suspected recurrent anaplastic astrocytoma and glioblastoma.

Abstract

Both amino acid positron emission tomography (PET) and magnetic resonance imaging (MRI) blood volume (BV) measurements are used in suspected recurrent high-grade gliomas. We compared the separate and combined diagnostic yield of simultaneously acquired dynamic contrast-enhanced (DCE) perfusion MRI and O-(2-[¹⁸F]-fluoroethyl)-L-tyrosine ([¹⁸F]FET) PET in patients with anaplastic astrocytoma and glioblastoma following standard therapy. A total of 76 lesions in 60 hybrid [¹⁸F]FET PET/MRI scans with DCE MRI from patients with suspected recurrence of anaplastic astrocytoma and glioblastoma were included retrospectively. BV was measured from DCE MRI employing a 2-compartment exchange model (2CXM). Diagnostic performances of maximal tumour-to-background [¹⁸F]FET uptake (TBR_max), maximal BV (BV_max) and normalised BV_max (nBV_max) were determined by ROC analysis using 6-month histopathological (n = 28) or clinical/radiographical follow-up (n = 48) as reference. Sensitivity and specificity at optimal cut-offs were determined separately for enhancing and non-enhancing lesions. In progressive lesions, all BV and [¹⁸F]FET metrics were higher than in non-progressive lesions. ROC analyses showed higher overall ROC AUCs for TBR_max than both BV_max and nBV_max in both lesion-wise (all lesions, p = 0.04) and in patient-wise analysis (p < 0.01). Combining TBR_max with BV metrics did not increase ROC AUC. Lesion-wise positive fraction/sensitivity/specificity at optimal cut-offs were 55%/91%/84% for TBR_max, 45%/77%/84% for BV_max and 59%/84%/72% for nBV_max. Combining TBR_max and best-performing BV cut-offs yielded lesion-wise sensitivity/specificity of 75/97%. The fraction of progressive lesions was 11% in concordant negative lesions, 33% in lesions only BV positive, 64% in lesions only [¹⁸F]FET positive and 97% in concordant positive lesions. The overall diagnostic accuracy of DCE BV imaging is good, but lower than that of [¹⁸F]FET PET. Adding DCE BV imaging did not improve the overall diagnostic accuracy of [¹⁸F]FET PET, but may improve specificity and allow better lesion-wise risk stratification than [¹⁸F]FET PET alone.