A Druggable Rheostat for Ewing Sarcoma?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35921177.
- Also identified by DOI 10.1158/1078-0432.CCR-22-1794 and PMC identifier 9588653.
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Abstract
The posterior HOXD enhancer is an EWSR1::FLI1-dependent regulator of HOXD13 expression in Ewing sarcoma. HOXD13 expression promotes a mesenchymal cell state. Through antagonistic transcriptional programs, EWSR1::FLI1 and HOXD13 serve as master regulators of Ewing cell plasticity. Targeting Ewing cells as they exist in/transition between mesenchymal states is a priority. See related article by Apfelbaum et al., p. 4466.
Medical subject headings
- Sarcoma, Ewing