Using the urea cycle to shift astrocytes from harmful to helpful in Alzheimer's disease.
Level V
Where this comes from
- Record sourced from PubMed, PMID 35921813.
- Also identified by DOI 10.1016/j.cmet.2022.07.001.
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Abstract
Astrocytes are brain cells that react to Alzheimer's disease pathology in ways that can have either beneficial or detrimental effects. In this issue of Cell Metabolism, Ju et al. outline a novel strategy for coercing astrocytes to a neuroprotective state by maintaining liver-like detoxification in the brain without producing damaging byproducts.
Medical subject headings
- Alzheimer Disease