T-bet B or not T-bet B, is that the question in obesity-related metabolic disease?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35921814.
- Also identified by DOI 10.1016/j.cmet.2022.07.008.
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Abstract
Obesity is linked to inflammation and downstream metabolic dysregulation. In this issue of Cell Metabolism, Hägglöf et al. show that iNKT cells enable the accumulation of T-bet<sup>+</sup> B cells in white adipose tissue, which in turn produce chemokine and antibody mediators that exacerbate the onset and severity of metabolic disease.
Medical subject headings
- Metabolic Diseases
- Natural Killer T-Cells