Gluconeogenesis: Adding a new piece to the puzzle of malaria parasitism.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 35921815.
- Also identified by DOI 10.1016/j.cmet.2022.07.004.
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Abstract
Disorders of carbohydrate metabolism, including hypoglycemia and lactic acidosis, are common features of malaria. In this issue of Cell Metabolism, Ramos et al. report that regulation of gluconeogenesis and glycemia by the host glucose-6-phosphatase catalytic subunit 1 (G6Pc1) is a key metabolic step that affects both Plasmodium replication and clinical outcome of disease.
Medical subject headings
- Acidosis, Lactic
- Hypoglycemia
- Malaria