Outrunning obesity with Lac-Phe?
Where this comes from
- Record sourced from PubMed, PMID 35921816.
- Also identified by DOI 10.1016/j.cmet.2022.07.007.
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Abstract
Lactate released from skeletal muscle during high-intensity exercise gives rise to a surge in circulating lactate-derived pseudo-dipeptide metabolites including N-lactoyl-phenylalanine (Lac-Phe). In a recent Nature paper, Li et al. use genetic and pharmacological evidence to now propose Lac-Phe to be an "exercise hormone" that suppresses appetite and obesity.
Medical subject headings
- Lactic Acid
- Phenylalanine