Cobalt-catalyzed branched selective hydroallylation of terminal alkynes.
basic_science · Level V
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- Record sourced from PubMed, PMID 35922446.
- Also identified by DOI 10.1038/s41467-022-32291-3 and PMC identifier 9349270.
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Abstract
Here, we reported a cobalt-hydride-catalyzed Markovnikov-type hydroallylation of terminal alkynes with allylic electrophile to access valuable and branched skipped dienes (1,4-dienes) with good regioselectivity. This operationally simple protocol exhibits excellent functional group tolerance and exceptional substrate scope. The reactions could be carried out in gram-scale with TON (turn over number) up to 1160, and the products could be easily derivatized. The preliminary mechanism of electrophilic allylation of α-selective cobalt alkenyl intermediate was proposed based on deuterium labeling experiment and kinetic studies.