Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35931026.
- Also identified by DOI 10.1016/j.stem.2022.07.002 and PMC identifier 9811982.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In the current issue of Cell Stem Cell, Bogeska et al. demonstrate that repeated exposures to inflammation cause indelible and specific functional compromise and accelerated aging of long-term hematopoietic stem cells (LT-HSCs). This study proposes the notion that the cumulative inflammatory events over the course of an organism's lifespan may irreversibly damage LT-HSCs.
Medical subject headings
- Aging
- Hematopoietic Stem Cells