Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons.
editorial · Level V
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- Record sourced from PubMed, PMID 35931027.
- Also identified by DOI 10.1016/j.stem.2022.07.001 and PMC identifier 12495995.
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Abstract
In this issue of Cell Stem Cell, Victor et al. reveal that human microglia harboring the Alzheimer's disease risk allele APOE4 have altered lipid metabolism and cellular activation. This dampens neuronal network activity, underscoring the importance of these brain-resident immune cells and highlighting a novel pathway for therapeutic intervention.
Medical subject headings
- Alzheimer Disease
- Apolipoprotein E4