Universal minimal cost of coherent biochemical oscillations.

Abstract

Biochemical clocks are essential for virtually all living systems. A biochemical clock that is isolated from an external periodic signal and subjected to fluctuations can oscillate coherently only for a finite number of oscillations. Furthermore, such an autonomous clock can oscillate only if it consumes free energy. What is the minimum amount of free-energy consumption required for a certain number of coherent oscillations? We conjecture a universal bound that answers this question. A system that oscillates coherently for N oscillations has a minimal free-energy cost per oscillation of 4π^{2}Nk_{B}T. Our bound is valid for general finite Markov processes, is conjectured based on extensive numerical evidence, is illustrated with numerical simulations of a known model for a biochemical oscillator, and applies to existing experimental data.