Centromeres organize (epi)genome architecture.

Talbert, Paul; Henikoff, Steven · Cell · 2022

basic_science · Level V

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Abstract

In some plants and animals, microtubules attach across the length of the chromosome in mitosis, forming a holocentromere instead of a single centromeric locus. A new study in Cell shows that in the holocentric beak sedge Rhynchospora, holocentromeres also impact genomic architecture, epigenome organization, and karyotype evolution.

Medical subject headings