Human Immunodeficiency Virus Type 1 RNA Levels in Rectal and Seminal Compartments After Switching to Long-Acting Cabotegravir Plus Rilpivirine: A Longitudinal Study.

Masiá, Mar; Fernández-González, Marta; Agulló, Vanesa; Mascarell, Paula; Padilla, Sergio; García-Abellán, Javier; Gutiérrez, Félix · Clin Infect Dis · 2023

prospective_cohort · Level II

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Abstract

Human immunodeficiency virus type 1 RNA levels were longitudinally evaluated in 211 rectal and 152 seminal samples from 12 virologically suppressed participants switching to monthly long-acting cabotegravir plus rilpivirine or continuing with daily dolutegravir-abacavir-lamivudine. Maintenance of viral suppression in rectal and seminal compartments was comparable, and blips occurred with similar frequency with both treatment regimens. NCT02938520.

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