Kidney disease progression and collider bias in GWAS.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35988936.
- Also identified by DOI 10.1016/j.kint.2022.06.018.
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Abstract
New genome-wide meta-analysis for longitudinal kidney function decline identified several genetic loci related to kidney disease progression. The study illustrated the complexity of modeling longitudinal traits in genome-wide association studies and highlighted the issue of a collider bias that can be introduced when a kidney disease progression phenotype is adjusted for baseline kidney function. Herein, we briefly outline the key findings of this study, their limitations, and implications for future studies.
Medical subject headings
- Genome-Wide Association Study
- Kidney Diseases