Association of Olfactory Performance With Motor Decline and Age at Onset in People With Parkinson Disease and the <i>LRRK2</i> G2019S Variant.

Abstract

There is clinical and phenotypic heterogeneity in <i>LRRK2</i> G2019S Parkinson disease (PD), including loss of smell. Olfactory scores have defined subgroups of <i>LRRK2</i> PD at baseline. We now extend this work longitudinally to better determine features associated with olfactory classes and to gain further insight into this heterogeneity. Evaluation of 162 patients with <i>LRRK2</i> PD and 198 patients with idiopathic PD (IPD) from the <i>LRRK2</i> Ashkenazi Jewish Consortium was performed, with follow-up available for 92 patients with <i>LRRK2</i> PD and 74 patients with IPD. Olfaction (University of Pennsylvania Smell Identification Test [UPSIT]), motor function (Unified Parkinson Disease Rating Scale), and cognition (Montreal Cognitive Assessment), as well as sleep, nonmotor, and mood, were measured. Gaussian mixture models were applied on the UPSIT percentile score to determine subgroups based on olfactory performance. Linear mixed effects models, using PD duration as the time scale, assessed the relationship between UPSIT subgroup membership and motor/cognitive change. Baseline olfaction was better in <i>LRRK2</i> PD compared with IPD (mean UPSIT ± SD: 24.2 ± 8.8 vs 18.9 ± 7.6), with higher mean percentile scores (difference: 15.3 ± 11.6) (<i>p</i> < 0.001) and less frequent hyposmia (55.6% vs 85.4%; <i>p</i> < 0.001). Analysis suggested 3 classes among <i>LRRK2</i> PD. Age at onset in <i>LRRK2</i> PD was earlier in the worst olfaction group (group 1), compared with groups 2 and 3 (54.5 ± 11.1 vs 61.7 ± 9.3) (<i>p</i> = 0.012), and separately in the hyposmic group overall (55.0 ± 11.3 vs 61.7 ± 9.1) (<i>p</i> < 0.001). Longitudinal motor deterioration in <i>LRRK2</i> PD was also significantly faster in the worst UPSIT group than the best UPSIT group (group 3 vs group 1: B = 0.31, SE = 0.35 vs B = 0.96, SE = 0.28) (rate difference = -0.65, SE = 0.29) (<i>p</i> = 0.03). However, olfactory group membership was not significantly associated with cognitive decline. In this large <i>LRRK2</i> cohort with longitudinal analysis, we extend prior work demonstrating subgroups defined by olfaction in <i>LRRK2</i> G2019S PD and show that the worst olfaction group has earlier age at PD onset and more rapid motor decline. This supports a subgroup of <i>LRRK2</i> PD that might show more rapid change in a clinical trial of <i>LRRK2</i>-related agents and highlights the need to integrate careful phenotyping into allocation schema in clinical trials of <i>LRRK2</i>-related agents. This study provides Class II evidence that worse olfactory scores were associated with an earlier age at symptomatic onset and a faster rate of motor deterioration in patients with <i>LRRK2</i> PD.