How splicing confers treatment resistance in prostate cancer.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35998026.
- Also identified by DOI 10.7554/eLife.82070 and PMC identifier 9398401.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
A splice variant of the androgen receptor that drives prostate cancer resistance translocates into the nucleus using a different mechanism from the full-length receptor and exhibits distinct molecular properties once inside.
Medical subject headings
- Prostatic Neoplasms, Castration-Resistant