CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non-Small Cell Lung Cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36006988.
- Also identified by DOI 10.1158/0008-5472.CAN-21-4029.
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Abstract
The identification of a role for CYP4F2-dependent metabolism in driving immune evasion in non-small cell lung cancer reveals a strategy to improve the efficacy of immunotherapy by inhibiting CYP4F2. See related article by Van Ginderachter, p. 3882.
Medical subject headings
- Carcinoma, Non-Small-Cell Lung
- Cytochrome P450 Family 4
- Lung Neoplasms