Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36007109.
- Also identified by DOI 10.1158/0008-5472.CAN-21-1225 and PMC identifier 10204098.
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Abstract
Dll1+ breast cancer cells activate Notch signaling in cancer-associated fibroblasts that increases Wnt ligand secretion and leads to β-catenin-driven radioresistance and metastasis, opening new therapeutic avenues for breast cancer.
Medical subject headings
- Breast Neoplasms
- Cancer-Associated Fibroblasts