Programmable antivirals to target conserved essential shapes in pandemic viral genomes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36008723.
- Also identified by DOI 10.1038/s41591-022-01910-3 and PMC identifier 9406275.
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Abstract
We identified and mapped at high-resolution RNA structures in viral genomes that are essential for virus reproduction. We then rapidly designed potent antivirals with high barriers to resistance that prevent or treat severe infections of these viruses with pandemic potential — via development of what we term ‘programmable antivirals’.
Medical subject headings
- Influenza, Human
- Pandemics