Changes in Radical Levels as a Cause for the FLASH effect: Impact of beam structure parameters at ultra-high dose rates on oxygen depletion in water.

Jansen, Jeannette; Beyreuther, Elke; García-Calderón, Daniel; Karsch, Leonhard; Knoll, Jan; Pawelke, Jörg; Schürer, Michael; Seco, Joao · Radiother Oncol · 2022

basic_science · Level V

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Abstract

The influence of different average and bunch dose rates in electron beams on the FLASH effect was investigated. The present study measures O<sub>2</sub> content in water at different beam pulse patterns and finds strong correlation with biological data, strengthening the hypothesis of radical-related mechanisms as a reason for the FLASH effect.

Medical subject headings