CoRa-A general approach for quantifying biological feedback control.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36037352.
- Also identified by DOI 10.1073/pnas.2206825119 and PMC identifier 9457221.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Feedback control is a fundamental underpinning of life, underlying homeostasis of biological processes at every scale of organization, from cells to ecosystems. The ability to evaluate the contribution and limitations of feedback control mechanisms operating in cells is a critical step for understanding and ultimately designing feedback control systems with biological molecules. Here, we introduce CoRa-or Control Ratio-a general framework that quantifies the contribution of a biological feedback control mechanism to adaptation using a mathematically controlled comparison to an identical system that does not contain the feedback. CoRa provides a simple and intuitive metric with broad applicability to biological feedback systems.
Medical subject headings
- Feedback, Physiological
- Homeostasis
- Models, Biological