Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36038141.
- Also identified by DOI 10.1093/bjs/znac293 and PMC identifier 10364487.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
A major restriction to transplantation is the requirement for ABO blood group compatibility between donor and recipient. In this study, an α-galactosidase enzyme from <i>Bacteroides fragilis</i> was used successfully to remove type B blood group antigens enzymatically from human kidneys using <i>ex vivo</i> normothermic machine perfusion. This provides the first step for a strategy to overcome the ABO barrier in kidney transplantation.
Medical subject headings
- Kidney
- Kidney Transplantation