Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 36038628.
- Also identified by DOI 10.1038/s41591-022-01941-w and PMC identifier 9499853.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder (BED). In this pilot study, we used responsive deep brain stimulation (DBS) to record nucleus accumbens (NAc) electrophysiology during food cravings preceding LOC eating in two patients with BED and severe obesity (trial registration no. NCT03868670). Increased NAc low-frequency oscillations, prominent during food cravings, were used to guide DBS delivery. Over 6 months, we observed improved self-control of food intake and weight loss. These findings provide early support for restoring inhibitory control with electrophysiologically-guided NAc DBS. Further work with increased sample sizes is required to determine the scalability of this approach.
Medical subject headings
- Deep Brain Stimulation
- Obesity, Morbid