Genomic characterization of SARS-CoV-2 from vaccine breakthrough cases in Allegheny County, Pennsylvania.

Waggle, Kady D; Griffith, Marissa P; Zhu, Lei; Cooper, Vaughn S; Snyder, Daniel J; Srinivasa, Vatsala; Phan, Tung; Wells, Alan et al. · PLoS One · 2022

case_control · Level III

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Abstract

We performed whole genome sequencing on SARS-CoV-2 from 59 vaccinated individuals from southwest Pennsylvania who tested positive between February and September, 2021. A comparison of mutations among vaccine breakthrough cases to a time-matched control group identified potential adaptive responses of SARS-CoV-2 to vaccination.

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