Construction of Wogonin Nanoparticle-Containing Strontium-Doped Nanoporous Structure on Titanium Surface to Promote Osteoporosis Fracture Repair.
basic_science · Level V
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- Record sourced from PubMed, PMID 36048734.
- Also identified by DOI 10.1002/adhm.202201405.
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Abstract
M2 polarization of macrophage is an important immunomodulatory event that attenuates inflammation. To regulate the immune microenvironment in osteoporotic conditions for enhancing bone healing, strontium-doped nano-structure is fabricated on the surface of titanium implant via microarc oxidation and electrochemical deposition technology, followed by the addition of multiplayer coatings embedded with silk fibroin-based wogonin nanoparticles (Ti-MAO/Sr/LBL<sub>WNP</sub> ) by layer-by-layer self-assembly technique (LBL). It is found that Ti-MAO/Sr/LBL<sub>WNP</sub> can release wogonin and Sr<sup>2+</sup> in a sustainable manner for more than 7 and 21 days. In vitro studies show that Ti-MAO/Sr/LBL<sub>WNP</sub> significantly upregulates the expression of CD206 while reducing the expression of CD86. Meanwhile, Ti-MAO/Sr/LBL<sub>WNP</sub> can promote the expression level of M2 macrophage anti-inflammatory factor (TGF-β1, Arg-1), which improves the proliferation and osteogenic differentiation of osteoblasts through paracrine signaling. Compared to bare titanium, Ti-MAO/Sr/LBL<sub>WNP</sub> significantly inhibits the expression of inflammatory factors around the implant and effectively promotes new bone formation at pre-implant interface after implantation for 4 weeks. This study provides a simple and effective method to develop functional titanium alloy materials for osteoporotic fracture repair.
Medical subject headings
- Osteoporotic Fractures
- Nanopores
- Nanoparticles
- Osteoporosis