SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individuals.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 36050304.
- Also identified by DOI 10.1038/s41467-022-32389-8 and PMC identifier 9435409.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Immune responses at the respiratory mucosal interface are critical to prevent respiratory infections but it is unclear to what extent antigen specific mucosal secretory IgA (SIgA) antibodies are induced by mRNA vaccination in humans. Here we analyze paired serum and saliva samples from patients with and without prior coronavirus disease 2019 (COVID-19) at multiple time points pre and post severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. Our results suggest mucosal SIgA responses induced by mRNA vaccination are impacted by pre-existing immunity. Indeed, vaccination induced a minimal mucosal SIgA response in individuals without pre-exposure to SARS-CoV-2 while SIgA induction after vaccination was more efficient in patients with a history of COVID-19.
Medical subject headings
- COVID-19
- COVID-19 Vaccines
- SARS-CoV-2