Pursuing FOXR2-Driven Oncogenesis.
editorial · Level V
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- Record sourced from PubMed, PMID 36052493.
- Also identified by DOI 10.1158/0008-5472.CAN-22-2259.
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Abstract
FOXR2 encodes a Forkhead-Box transcription factor that has been recently described as a proto-oncogene. In this issue of Cancer Research, Tsai and colleagues present the first pan-cancer study summarizing the prevalence of FOXR2 overexpression beyond rare childhood-onset malignancies. Identification of a previously unknown mechanism of epigenetic activation and the expansion of FOXR2 transcriptional targets enhance the mechanistic understanding of FOXR2-driven malignancy, with the potential to uncover new therapeutic opportunities. See related article by Tsai et al., p. 2980.
Medical subject headings
- Carcinogenesis
- Oncogenes