Keratinocyte PIEZO1 modulates cutaneous mechanosensation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36053009.
- Also identified by DOI 10.7554/eLife.65987 and PMC identifier 9512397.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile information to sensory neurons. However, the specific mechanotransducers that enable keratinocytes to respond to mechanical stimulation are unknown. Here, we found that the mechanically-gated ion channel PIEZO1 is a key keratinocyte mechanotransducer. Keratinocyte expression of PIEZO1 is critical for normal sensory afferent firing and behavioral responses to mechanical stimuli in mice.
Medical subject headings
- Keratinocytes
- Skin